一、个人简介
张慧杰,男,1986年05月出生,博士、副教授、硕士生导师,江苏省药学会海洋药物专业委员会委员,江苏省市场监督管理学会会员,无锡市欧美同学会医药与卫生分会理事,担任Pharmaceuticals期刊客座编辑,担任Nano Today, Chemical Engineering Journal, ACS Applied Materials & Interfaces等期刊审稿人。
学习经历:
2003/09–2007/06,安徽师范大学,化学与材料科学学院,学士
2007/09–2010/06,四川大学,国家生物医学材料工程技术研究中心,硕士
2010/10–2013/09,日本北海道大学,生命科学院,博士
工作经历:
2010/10-2013/09,日本国家材料研究所,生物材料中心,研究助理
2013/10-2017/03,江南大学,生物工程学院,副教授
2017/04-2021.12,江南大学,药学院,副教授,硕士生导师
2019/07-2020.07,无锡市新吴区硕放街道办事处,副主任(挂职)
2021/03-2022/03,江南大学校长办公室主任助理(挂职)
2022.01-至今,best365体育官网平台,副教授,硕士生导师
二、研究领域
生物材料,药物传递,纳米医学
三、荣誉奖励
2020江苏省第十二批科技镇长团省级优秀团员
2018-2019, 2020-2021江南大学至善青年学者
2019江南大学教学成果奖二等奖
2020江南大学本科优秀毕业论文指导教师
2019第五届“互联网+”大学生创新创业大赛获得省级三等奖
2015药明康德奖教金
四、学术成果
(一)代表性项目
[1]噬菌体展示肽功能化糖原精准递送CpG ODN逆转Th7/Th2免疫应答失衡治疗花粉症的研究(21907041),国家自然科学基金
[2]氮化硼纳米球提高CpG ODNs的免疫刺激活性联合阿霉素协同抗肿瘤的研究(BK20170202),江苏省自然科学基金
[3]智能型CpG ODN/阿霉素纳米载药体系的构建及其靶向抗肿瘤研究,教育部“留学回国人员科研启动基金”
[4]整形用透明质酸水凝胶的开发,企业项目
[5]创可贴和造口袋底盘用水胶体研制,企业项目
(二)代表性论文
[1]H. Zhang, W. Chen, K. Gong, J. Chen, Nanoscale Zeolitic Imidazolate Framework-8 as Efficient Vehicles for Enhanced Delivery of CpG Oligodeoxynucleotides,ACS Applied Materials & Interfaces, 2017 (9) 31519-31525.
[2]H. Zhang, D. Huang, C. Yuan, T. Yan, S. Feng, H. Nakanishi, X.-D. Gao, Genetically engineered yeast spores as chitosan microspheres for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides,Journal of Controlled Release, 2017 (259) e50.
[3]H. Zhang, T. Cheng, L. Lai, S. Deng, R. Yu, L. Qiu, J. Zhou, G. Lu, C. Zhi, J. Chen, BN nanospheres functionalized with mesoporous silica for enhancing CpG oligodeoxynucleotide-mediated cancer immunotherapy,Nanoscale10 (2018) 14516-14524.
[4]Zhang, H.; Ding, A.; Ye, B.; Wang, Z.; Zhang, J.; Qiu, L.; Chen, J. Carbon Nitride Nanosheets for Imaging Traceable CpG Oligodeoxynucleotide Delivery.ACS Applied Nano Materials2021, 4 (8), 8546-8555.
[5]H. Zhang, T. Yan, S. Feng, D. Huang, C. Zhi, X.-D. Gao, Mesoporous silica functionalized boron nitride nanospheres for enhancing the immunostimulatory and antitumor effects of CpG ODNs,Nanomedicine: Nanotechnology, Biology and Medicine14 (2018) 1823-1824.
[6]H. Zhang, L. Lai, Y. Wang, B. Ye, S. Deng, A. Ding, L. Teng, L. Qiu, J. Chen, Silk fibroin for CpG oligodeoxynucleotides delivery,ACS Biomaterials Science & Engineering 2019 (11), 6082-6088
[7]H. Zhang, X.-D. Gao, Nanodelivery systems for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides,Materials Science and Engineering: C, 2017 (70) 935-946.
[8]H. Zhang, T. Yan, S. Xu, S. Feng, D. Huang, M. Fujita, X.-D. Gao, Graphene oxide-chitosan nanocomposites for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides,Materials Science and Engineering: C, 2017 (73) 144-151.
[9]H. Zhang, M. Peng, T. Cheng, P. Zhao, L. Qiu, J. Zhou, G. Lu, J. Chen, Silver nanoparticles-doped collagen–alginate antimicrobial biocomposite as potential wound dressing,Journal of Materials Science53 (2018) 14944-14952.
[10] Qiu, L.; Xu, J.; Ahmed, K. S.; Zhu, M.; Zhang, Y.; Long, M.; Chen, W.; Fang, W.;H. Zhang*; Chen, J*. Stimuli-responsive, dual-function prodrug encapsulated in hyaluronic acid micelles to overcome doxorubicin resistance.Acta Biomaterialia2022, 140, 686-699.
[11 T. Cheng, J. Miao, D. Kai,H. Zhang*, Polyethylenimine-Mediated CpG Oligodeoxynucleotide Delivery Stimulates Bifurcated Cytokine Induction,ACS Biomaterials Science & Engineering, 2018 (4) 1013-1018.
[12] S. Feng, H. Li, Y. Ren, C. Zhi, Y. Huang, F. Chen*,H. Zhang*, RBC membrane camouflaged boron nitride nanospheres for enhanced biocompatible performance,Colloids and Surfaces B: Biointerfaces190 (2020) 110964.
[13] S. Naz, M. Wang, Y. Han, B. Hu, L. Teng, J. Zhou*,H. Zhang*, J. Chen, Enzyme-responsive mesoporous silica nanoparticles for tumor cells and mitochondria multistage-targeted drug delivery, International Journal of Nanomedicine 14 (2019) 2533-2542.
[14] S. Feng,H. Zhang*, C. Zhi, X.-D. Gao, H. Nakanishi*, pH-responsive charge-reversal polymer-functionalized boron nitride nanospheres for intracellular doxorubicin delivery,International Journal of Nanomedicine, 2018 (13) 641-652.
[15] T. Yan,H. Zhang*, D. Huang, S. Feng, M. Fujita, X.-D. Gao*, Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant, Nanomaterials, 2017 (7) 59.
(三)主要授权专利
用于生产糖蛋白的动物细胞株及方法、糖蛋白及其用途. PCT/CN2018/084551
海藻酸钠/胶原/石墨相氮化碳纳米片光催化抗菌膜的制备. CN110169979A
一种高粘附性抗菌促愈合水凝胶及其制备方法. CN202110410154.8
一种具有靶向性的CpG核酸药物递送系统及其制备方法. CN202110584701.4
一种高粘附性抗菌促愈合水凝胶及其制备方法. PCT/CN2021/121632
一种可见光响应的光催化抗菌促愈合水凝胶及其制备方法. CN202011412136.5
五、联系方式
通讯地址:江苏省无锡市蠡湖大道1800号best365体育官网平台
邮编:214122
邮箱:zhj0502@jiangnan.edu.cn
【以上资料更新日期】2022年3月