RESEARCH INTEREST

My research interest mainly focused on the polysaccharide-polysaccharide interactions, which would further branch into the following sub-area including structure-activity relationship study, discovery of new mechanisms of drugs involved in inflammatory disease, and the design polysaccharide payload biomaterials to perform multiple tasks relating to human health problems, especially the mRNA delivery system engineering.

PUBLICATIONS

Published Papers in The Past Five Years (In reverse chronological order)

1.A hydrogel microparticle with sustained release properties for pulmonary drug delivery[J].Yan Y, Wu Q, Miao S, et al. Reactive and Functional Polymers, 2023, 183: 105489.

2.A Severe Acute Pancreatitis Mouse Model Transited from Mild Symptoms Induced by a“Two-Hit” Strategy with L-Arginine. Life 2022, 12, 126. Yang, J.; Tang, X.; Wu, Q.; Ren, P.;Yan, Y*.2022,https://doi.org/10.3390/life12010126

3.Yang J, Tang X, Wu Q,Yan Y*. et al. Heparin Protects Severe Acute Pancreatitis by Inhibiting HMGB-1 Active Secretion from Macrophages[J]. Polymers, 2022, 14(12): 2470.

4.Structure comparison and anti-coagulant effects of the glycosaminoglycans from porcine duodenum and jejunum. Food Chemistry,Yan, Y*., Ren, P., Wu, Q., Liu, X., Zhang, Z., Hua, M., & Chen, J. (2022).373, 131609

5.Zinc ions coordinated carboxymethyl chitosan-hyaluronic acid microgel for pulmonary drug delivery. International Journal of Biological Macromolecules,Yan, Y*., Wu, Q., Ren, P., Liu, Q., Zhang, N., Ji, Y., & Liu, J. (2021). 193, 1043-1049.

6.A heparin derivatives library constructed by chemical modification and enzymatic depolymerization for exploitation of non-anticoagulant functions[J]. Ji Y, Wang Y, Zeng W,Yishu Yet al. Carbohydrate Polymers, 2020, 249: 116824.

7.Pien Tze Huang accelerated wound healing by inhibition of abnormal fibroblast apoptosis in Streptozotocin induced diabetic mice. Yan Y, Liu X, Zhuang Y, Zhai Y, Yang X, Yang Y, Wang S, Hong F, Chen J. J Ethnopharmacol. 2020 Oct 28; 261:113203.

8.pH-Driven Precise Control of Hybridization Reaction Kinetics for Rapid DNA AssayYishu, Yan; Yuan Lu; Xiao Niliu; Yan Zhang; Jinghua Chen,Chemistry Select, 2018, 3：10646~10650.

9.Design of fusion proteins for efficient and soluble production of immunogenic Ebola virus glycoprotein inEscherichia coli[J]. Ji Y, Lu Y,Yan Y, et al. Biotechnology Journal, 2018, 13(6): 1700627.

10.Design and synthesis of a native heparin disaccharide grafted poly 2 aminoethyl methacrylate glycopolymer for inhibition of melanoma cell metastasis, Zhi Cai(#); Liping Teng(#); Juan Zhou;Yishu Yan*; Yan Zhang; Guozhong Lv; Jinghua Chen(*), International Journal of Biological Macromolecules, 2018, 126：612~619,

PATENTS

1.Enzymatic depolymerized heparins treatment for pulmonary fibrosis, CN201710374727.X

2. Application of a heparin mimetic for the treatment or prevention of acute pancreatitis, CN202110527675.1

3. A large aperture injectable gel and its application in wound healing, CN202310630010.2

FUNDINGS SUPPORTED BY

1. National Nature Science Foundation of China (No. 21978114)

2. National Nature Science Foundation of China (No. 21506112)

ADJUNVANT ACADEMIC POSITIONS

Young editor for Journal of The Future Foods

Room 327, School of Life Sciences and Health Engineering, Jiangnan University, Wuxi City, Jiangsu Province China

Cell: +86-15101640749;

Email:yanyishu@sina.com