Position

Professor

Academic degree

Doctorate

Graduate school

Jiangnan university

Telephone

Research Orientation

Microbial   Pharmaceutics

Personal experiences

Education

2003.3-2006.6 Jiangnan university Ph.D with the subject of fermentation   engineering.

1989.9-1992.7 Shenyang   pharmaceutical college M.E. with   the subject of pharmaceutical chemistry.

1985.9-1989.7 Shenyang   pharmaceutical college B.E. with   the subject of pharmaceutical chemistry.

Scientific Career

2021-Now School of Life Science and   Health Engineering, Jiangnan university Professor

-in charge of converting sucrose to   L-serine and its derivative　with recombinant strain.

2006.6-2021 School of Pharmaceutical,   Jiangnan university Associate Professor

-in charge of converting sucrose   (glycerol) to L-serine with recombinant strain.

1996.5-2003.3 Sino American Shanghai   Squibb Supervisor

-in charge of marketing

1992.8-1996.5 Wuxi Pharmaceutical Institute   Engineer

-in charge of new drug synthesis

Scientific research activities

Recent Publications

[1] Yujie Gao, Xiaomei Zhang*, Guoqiang Xu,   Xiaojuan Zhang, Hui Li, Jinsong Shi and Zhenghong Xu*.

L-serine   production by Corynebacterium glutamicum based on novel insights into   L-serine exporters. Biotechnol   J, 2023,202300136

[2]   Xiaomei Zhang, Zhenhang Sun, Jinyu Bian, Yujie Gao, Dong Zhang, Guoqiang Xu,   Xiaojuan Zhang, Hui Li, Jinsong Shi and Zhenghong Xu*. Rational metabolic   engineering combined with biosensor-mediated Adaptive Laboratory Evolution   for L-cysteine overproduction from glycerol in Escherichia coli.   Fermentation, 2022, 8:299

[3] Xiaomei   Zhang, Yujie Gao, Zi wei chen, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong   Shi, Mattheos A. G. Koffas*, Zhenghong Xu*. High-yield production of L-serine   through a novel identified exporter combined with synthetic pathway in Corynebacterium   glutamicum, Microb. Cell Fact,2020,19, (1):115

[4] Xiaomei   Zhang, Yujie Gao, Ling Yang, Yi Yang, Ping Zheng,i chen,Jibin, Jinsong Shi,   Zhenghong Xu*. Amino   acid exporters and metabolic modification of Corynebacterium glutamicum-a   review Chinese Journal of   Biotechnology, 2020 36(11): 2250-2259

[5] Xiaomei   Zhang,Lianhe Lai, Guoqiang Xu, Xiaojuan Zhang, Jinsong Shi, Mattheos A. G.   Koffas*, Zhenghong Xu*. Rewiring the central metabolic pathway for high-yield   L-serine production inCorynebacterium glutamicumby using glucose, Biotechnol   J, 2019,1800497

[6] Xiaomei   Zhang#, Guoqiang Xu#, Jinsong Shi, Mattheos A. G. Koffas*, Zhenghong   Xu*. Microbial production of L-serine from renewable feedstocks. Trends   Biotechnol, 2018, 36 (7): 700-712

[7] Xin   Zhang, Xiaomei Zhang*, Guoqiang Xu, Xiaojuan Zhang, Jinsong Shi, Zhenghong   Xu*, Integration of ARTP mutagenesis with biosensor-mediated high-throughput   screening to improve L-serine yield in Corynebacterium glutamicum. Appl   Microbiol Biotechnol,2018,102:5939-5951

[8] Guoqiang   Xu, Qinjian Zhu, Yuchang Luo, Xiaojuan Zhang, Wen Guo, wenfang Dou, Hui LI,   Hongyu Xu,Xiaomei Zhang*, Zhenghong Xu*, Enhanced production of L-serine by   deleting sdaA combined with modifying and overexpressing serA in   a mutant of Corynebacterium glutamicumSYPS-062 from sucrose. Biochem   Eng J, 2017, (118) :113-122

[9] Xiaomei   Zhang, Lianhe Lai, Guoqiang Xu, Xiaojuan Zhang, Jinsong Shi, Zhenghong Xu*.   Effects of pyruvate kinase on the growth of Corynebacterium glutamicum and   L-serine accumulation. Process Biochem, 2017, 55:32-40

Recent projects

[1] National Natural Science Foundation of China   [32171470]

[2] National Key　Research and Development Program of   China[2018YFA0901400]

[3] National Key　Research and Development Program of China[2018YFA0900303]

[4] Enterprise   project [181345]

Engineering Background

　Has undertaken or participated in several   industrial collaboration projects, while parts of the achievements have been   applied to commercial production.

Teaching activities

Teaching Courses

Undergraduate courses: 《Pharmaceutical   Technology》

《Pharmaceutical Administration   and Regulation》

Postgraduate courses: 《New Techniques in Pharmacy》

Professional direction

Microbiological   and Biochemical Pharmacy

Supervising   of Postgraduate Students: 1-2 per year;

Supervising   of Undergraduate Students: 3-4 per year.

Updated: March 2024