Jing Wu, Associate Professor
School of Pharmaceutical Sciences, Jiangnan University
No. 1800 Lihu Avenue, Wuxi, jiangsu, RPC
E-Mail: wujing@jiangnan.edu.cn
Education
May 2013 – Jun. 2014 |
Postdoc. |
Northwestern University, USA Department of Chemical and Biological Engineering |
Sep. 2003 –Sep. 2008 |
Ph.D. |
Jiangnan University, China School of Biotechnology |
Sep. 1999 –Jun. 2003 |
B.S. |
Jiangnan University, China School of Biotechnology |
Work Experience
Jan. 2017 - Now |
Associate Professor |
Jiangnan University School of Pharmaceutical Sciences |
Sep. 2012 – Dec. 2016 |
Associate Professor |
Jiangnan University Wuxi Medical School |
Oct. 2008 – Aug. 2012 |
Lecturer |
Jiangnan University School of Medicine and Pharmaceutics |
Area of Research
1. Production of pharmaceutical intermediates by biotechnology.
2. Enzyme discovery, reconstruction and application.
Research Projects
1. National Natural Science Foundation of China (21576117), Mechanism of metal ions regulating the processivity and fidelity of Y family polymerase Dpo4.
2. National Natural Science Fund Youth Fund (31101229), Molecular modification on the heat / alkali resistance of xylanase from Aspergillus oryzae.
3. the branch project of Chinese High-tech R&D Program(863) (2012AA022 108), Genome engineering improves the production of pharmaceutical proteins by Bacillus subtilis.
4. Key research and development plan of Jiangsu Province (BE2015307), Study on the key technology of microbial preparation of vitamin C phosphate.
Journal Publications
1. Zhang Q, Yao R, Chen X, Liu L, Xu S, Chen J, Wu J*. Enhancing fructosylated chondroitin production in Escherichia coli K4 by balancing the UDP-precursors. Metab Eng. 2018, 47:314-322.
2. Wang L, Liang C, Wu J*, Liu L, Tyo KEJ. Increased Processivity, Misincorporation, and Nucleotide Incorporation Efficiency in Sulfolobus solfataricus Dpo4 Thumb Domain Mutants. Appl Environ Microbiol. 2017,83(18). pii: e01013-17.
3. Zheng K, Song W, Sun A, Chen X, Liu J, Luo Q, Wu J*. Enzymatic Production of Ascorbic Acid-2-phosphate by Recombinant Acid Phosphatase. J Agric Food Chem. 2017, 65(20):4161-4166.
4.Wu J, Wang H, Yang B, Song W, Liang C, Liu L. Efficient production of (R)-3-TBDMSO glutaric acid methyl monoester by manipulating the substrate pocket of Pseudozyma antarctica lipase B.RSC Adv., 2017, 7, 38264-38272
5. Yun J, Duan F, Liu L, Chen X, Liu J, Luo Q, Wu J*. A selective and sensitive nanosensor for fluorescent detection of specific IgEs to purified allergens in human serum. RSC Adv., 2018,8(7): 3547-3555.
6. Wu J, de Paz A, Zamft BM, Marblestone AH, Boyden ES, Kording KP, Tyo KEJ. DNA binding strength increases the processivity and activity of a Y-Family DNA polymerase. Sci Rep. 2017,7(1):4756.
7.Wang Y, Xu N, Ye C, Liu L, Shi Z, Wu J*. Reconstruction and in silico analysis of an Actinoplanes sp. SE50/110 genome-scale metabolic model for acarbose production. Front Microbiol. 2015,6:632.
8. Luo Q, Wu J*, Wu M. Enhanced acetoin production by Bacillus amyloliquefaciens through improved acetoin tolerance, Process Biochemistry,2014,49:1223-1230
9. Zhang Y, Li S, Liu L, Wu J*. Acetoin production enhanced by manipulating carbon flux in a newly isolated Bacillus amyloliquefaciens. Bioresour Technol. 2013 ,130: 256-260.
